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Insulin‐like growth factor‐1: roles in androgenetic alopecia
Author(s) -
Panchaprateep Ratchathorn,
Asawada Pravit
Publication year - 2014
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/exd.12339
Subject(s) - scalp , male pattern baldness , hair follicle , endocrinology , medicine , dermal papillae , growth factor , biology , insulin like growth factor , downregulation and upregulation , receptor , gene , genetics , anatomy
Of all the cytokines or growth factors that have been postulated to play a role in hair follicle, insulin‐like growth factor‐1 ( IGF ‐1) is known to be regulated by androgens. However, how IGF ‐1 is altered in the balding scalp has not yet been investigated. In this study, expressions of IGF ‐1 and its binding proteins by dermal papilla ( DP ) cells obtained from balding versus non‐balding hair follicles were quantified using growth factor array. DP cells from balding scalp follicles were found to secrete significantly less IGF ‐1, IGFBP ‐2 and IGFBP ‐4 ( P < 0.05) than their non‐balding counterparts. Our data confirmed that the downregulation of IGF ‐1 may be one of the important mechanisms contributing to male pattern baldness.