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Melanocortin 1 receptor and skin pathophysiology: beyond colour, much more than meets the eye
Author(s) -
GarcíaBorrón José Carlos,
Olivares Concepción
Publication year - 2014
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/exd.12310
Subject(s) - melanocortin 1 receptor , melanocortin , melanocortins , receptor , melanocyte stimulating hormone , fibrosis , endocrinology , medicine , pathophysiology , melanocortin 3 receptor , biology , knockout mouse , melanocortin receptor , phenotype , gene , genetics
Abstract The melanocortin 1 receptor ( MC 1R), a G protein‐coupled receptor preferentially expressed in melanocytes, mediates the pigmentary effects of α melanocyte‐stimulating hormone ( α MSH ). MC 1R is also expressed in other cutaneous cell types, particularly keratinocytes and dermal fibroblasts, suggesting non‐pigmentary actions of the α MSH / MC 1R system. Böhm and Stegemann now report a dramatic effect of mouse Mc1r functional status on susceptibility to skin fibrosis and collagen types I and III metabolism, in a study combining the powerful mouse model provided by the natural Mc1r e/e knockout and an established model of skin fibrosis. The study underscores the antifibrotic role for the skin α MSH / MC 1R system.