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Topical cholesterol treatment ameliorates hapten‐evoked cutaneous hypersensitivity by sustaining expression of 11β‐ HSD 1 in epidermis
Author(s) -
Murota Hiroyuki,
Itoi Saori,
Terao Mika,
Matsui Saki,
Kawai Hiromi,
Satou Yasunari,
Suda Kazuma,
Katayama Ichiro
Publication year - 2014
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/exd.12284
Subject(s) - transepidermal water loss , stratum corneum , barrier function , cholesterol , epidermis (zoology) , hapten , oxazolone , chemistry , endocrinology , medicine , inflammation , pharmacology , immunology , biology , antigen , pathology , microbiology and biotechnology , anatomy
Changes in the stratum corneum extracellular matrix impair epidermal barrier function and may cause dermatoses. The aim of this study was to examine the effect of exogenous cholesterol application on skin barrier function and cutaneous inflammation. Skin barrier‐disrupted or hapten‐stimulated mice were treated with topical cholesterol. The effect of topical cholesterol application on an oxazolone ( OXA )‐induced hypersensitivity reaction was evaluated. Topical application of cholesterol efficiently decreased transepidermal water loss in areas of barrier‐disrupted skin and ameliorated OXA ‐induced cutaneous hypersensitivity. These favourable effects may have resulted from sustained expression of 11β‐hydroxysteroid dehydrogenase type 1 (11β‐ HSD 1) in the cholesterol‐treated skin. As 11β‐ HSD 1 is known to produce active cortisol, topical cholesterol may attenuate contact hypersensitivity by normalizing secretion of hormonally active cortisol from the skin.