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Hair mi R ‐29a levels are decreased in patients with scleroderma
Author(s) -
Takemoto Risa,
Jinnin Masatoshi,
Wang Zhongzhi,
Kudo Hideo,
Inoue Kuniko,
Nakayama Wakana,
Ichihara Asako,
Igata Toshikatsu,
Kajihara Ikko,
Fukushima Satoshi,
Ihn Hironobu
Publication year - 2013
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/exd.12245
Subject(s) - dermatomyositis , scleroderma (fungus) , medicine , dermatology , pathology , inoculation
In the present study, we evaluated the possibility that we can utilize hair shaft mi R ‐29a levels as disease marker of scleroderma. Hair samples were obtained from 20 scleroderma patients, five dermatomyositis patients and 13 controls. micro RNA s were purified from hairs as well as skins or sera, and mi R ‐29a levels were measured with quantitative real‐time polymerase chain reaction. Mean hair mi R ‐29a levels in scleroderma patients were significantly lower than those in control subjects or dermatomyositis, while expression levels of hair shaft marker keratin 34 were similar among them. There was no strong correlation among the mi R ‐29a levels in the hair, skin and serum of each patient, suggesting that hair micro RNA s can be independent biomarkers. We found scleroderma patients with decreased mi R ‐29a levels had contracture of the phalanges at a significantly higher prevalence than those without. To confirm the clinical usefulness of hair micro RNA s, large‐scale researches are needed in the future.