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Ligand‐independent epidermal growth factor receptor hyperactivation increases sebaceous gland size and sebum secretion in mice
Author(s) -
Dahlhoff Maik,
Angelis Martin Hrabe,
Wolf Eckhard,
Schneider Marlon R.
Publication year - 2013
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/exd.12219
Subject(s) - sebaceous gland , medicine , endocrinology , hair follicle , epidermal growth factor receptor , regulator , epidermis (zoology) , epidermal growth factor , receptor , lipogenesis , chemistry , biology , microbiology and biotechnology , lipid metabolism , biochemistry , anatomy , gene
The epidermal growth factor receptor ( EGFR ) system is an established regulator of the development and homeostasis of the hair follicle and interfollicular epidermis. Here, we evaluated EGFR actions on the sebaceous glands ( SG s) by employing D sk5 mice, a mutant line in which the EGFR is constitutively activated in a ligand‐independent manner. Compared to control littermates, D sk5 mice showed increased sebum levels and enlarged SG s, which contained a higher number of cells and showed stronger proliferation. c‐myc transcript levels were increased in D sk5 skin, suggesting that c‐myc mediates the proliferative stimuli of the EGFR in the SG . Analysis of differentiation markers revealed deregulated expression of S cd1 and S cd3 , indicating that sebaceous lipogenesis is affected in D sk5 mice. In conclusion, our study indicates that the EGFR is an important regulator of presebocyte proliferation, contributing to the final cell number, to the size and to the lipid output of SG s.