Premium
Comparison between cold plasma, electrochemotherapy and combined therapy in a melanoma mouse model
Author(s) -
Daeschlein Georg,
Scholz Sebastian,
Lutze Stine,
Arnold Andreas,
Podewils Sebastian,
Kiefer Thomas,
Tueting Thomas,
Hardt Olaf,
Haase Hermann,
Grisk Olaf,
Langner Sönke,
Ritter Christoph,
Woedtke Thomas,
Jünger Michael
Publication year - 2013
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/exd.12201
Subject(s) - electrochemotherapy , bleomycin , melanoma , medicine , pharmacology , urology , chemotherapy , cancer research
The study was undertaken to compare antitumor efficacy of electrochemotherapy ( ECT ) with cold plasma therapy ( CP ) in a melanoma mouse model. After melanoma implantation into the flank of C57 BL /6N mice, CP by two different plasma sources ( APPJ and DBD ) was applied directly to the tumor surface. ECT was performed with bleomycin intravenously at a field strength of 1000 V/cm without or combined with CP . Primary endpoints were tumor growth acceleration ( TGA ), daily volume progression ( DVP ) and survival after treatment. Both plasma sources as single treatment showed a significant TGA delay, which proved less effective than ECT . CP ( APPJ ) combined with ECT ( ECJ ) significantly improved per cent mouse survival, with significant superiority compared with ECT . Plasma therapy alone albeit less effective seems a potential alternative to ECT in patients with melanoma and can be applied manifold in a session without general anaesthesia. Accordingly, CP alone and combined with ECT may serve as new option in palliative skin melanoma therapy.