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Role of CPI ‐17 in restoring skin homoeostasis in cutaneous field of cancerization: effects of topical application of a film‐forming medical device containing photolyase and UV filters
Author(s) -
PuigButillé Joan Anton,
Malvehy Josep,
Potrony Miriam,
Trullas Carles,
GarciaGarcía Francisco,
Dopazo Joaquin,
Puig Susana
Publication year - 2013
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/exd.12177
Subject(s) - photolyase , pyrimidine dimer , carcinogen , homeostasis , gene , gene expression , photoprotection , human skin , biology , cancer research , chemistry , microbiology and biotechnology , dna repair , biochemistry , genetics , photosynthesis
Cutaneous field of cancerization ( CFC ) is caused in part by the carcinogenic effect of the cyclobutane pyrimidine dimers CPD and 6‐4 photoproducts (6‐4 PP s). Photoreactivation is carried out by photolyases which specifically recognize and repair both photoproducts. The study evaluates the molecular effects of topical application of a film‐forming medical device containing photolyase and UV filters on the precancerous field in AK from seven patients. Skin improvement after treatment was confirmed in all patients by histopathological and molecular assessment. A gene set analysis showed that skin recovery was associated with biological processes involved in tissue homoeostasis and cell maintenance. The CFC response was associated with over‐expression of the CPI ‐17 gene, and a dependence on the initial expression level was observed ( P = 0.001). Low CPI ‐17 levels were directly associated with pro‐inflammatory genes such as TNF ( P = 0.012) and IL ‐1B ( P = 0.07). Our results suggest a role for CPI ‐17 in restoring skin homoeostasis in CFC lesions.