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Caspase‐14 overexpression in hairless mice is not involved in utricle formation
Author(s) -
Devos Michael,
De Groote Philippe,
Gilbert Barbara,
Bruggeman Inge,
Leurs Kirsten,
Lippens Saskia,
Vandenabeele Peter,
Declercq Wim
Publication year - 2013
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/exd.12165
Subject(s) - hairless , utricle , microbiology and biotechnology , hair follicle , repressor , biology , caspase 2 , histone , chromatin , caspase 8 , caspase 3 , saccule , apoptosis , inner ear , transcription factor , genetics , anatomy , programmed cell death , dna , gene
Loss of functional hairless ( HR ) transcriptional repressor leads to utricle formation and congenital hair loss both in mice and men. Studies in mice have shown that this is preceded by overexpression of caspase‐14 at the infundibulum in the hair follicle before conversion to utricle occurs. In this report, we show that HR regulates caspase‐14 expression dependent on its interaction with histone deacetylases, implicating chromatin remodelling in the transcriptional regulation of caspase‐14. However, crossing hairless mutant mice with caspase‐14‐deficient mice revealed that caspase‐14 overexpression is not the cause of utricle formation.