Premium
TRPV 3: a ‘more than skinny’ channel
Author(s) -
Nilius Bernd,
Bíró Tamás
Publication year - 2013
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/exd.12163
Subject(s) - transient receptor potential channel , trpv , ion channel , skin barrier , trpv4 , trpc1 , trpc5 , chemistry , microbiology and biotechnology , receptor , neuroscience , medicine , biology , trpv1 , dermatology , biochemistry
The skin is our largest organ serving different tasks from barrier formation through somatosensing to hair development. Recently, members of the large trp ( T ransient R eceptor P otential, TRP ) gene family encoding proteins that form cation selective ion channel have been identified to play a crucial role in skin functions. Within the 28 different mammalian TRP channels, TRPV 3 might be the most important member in the skin. This review gives an overview on functional properties of TRPV 3 in skin physiology and in certain skin diseases.