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Curcumin inhibits UVB‐induced matrix metalloproteinase‐1/3 expression by suppressing the MAPK‐p38/JNK pathways in human dermal fibroblasts
Author(s) -
Hwang BoMi,
Noh EunMi,
Kim JongSuk,
Kim JeongMi,
You YongOuk,
Hwang JinKi,
Kwon KangBeom,
Lee YoungRae
Publication year - 2013
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/exd.12137
Subject(s) - curcumin , p38 mitogen activated protein kinases , matrix metalloproteinase , chemistry , mapk/erk pathway , western blot , protein kinase a , kinase , pharmacology , matrix metalloproteinase inhibitor , cancer research , microbiology and biotechnology , biochemistry , biology , gene
Curcumin (diferuloylmethane) is a polyphenol derived from turmeric ( C urcuma longa ), which is commonly used as a spice. Recent studies have shown that curcumin has a wide range of pharmacological activities, including anticarcinogenic, antioxidant, anti‐inflammatory and antiangiogenic activities. However, the antiphotoageing effects of curcumin have yet to be characterized. In this study, we investigated the inhibitory effects of curcumin on matrix metalloproteinase ( MMP )‐1 and MMP‐3 expression in human dermal fibroblast cells. Western blot analysis revealed that curcumin inhibited ultraviolet ( UV ) B ‐induced MMP ‐1 and MMP ‐3 expression. Furthermore, curcumin significantly blocked UVB‐induced reactive oxygen species generation in fibroblasts. Curcumin treatment significantly blocked the UVB ‐induced activation of nuclear factor ( NF )‐κB and activator protein ( AP )‐1. Additionally, curcumin strongly repressed the UVB ‐induced phosphorylation of p38 and c‐Jun N‐terminal kinase. Curcumin prevented UVB ‐induced MMP expression through mitogen‐activated protein kinase/ NF ‐κB inhibition and AP ‐1 activation. In conclusion, curcumin may be useful for preventing and treating skin photoageing.