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Therapeutic and immune effects of 5‐aminolevulinic acid photodynamic therapy on UVB ‐induced squamous cell carcinomas in hairless mice
Author(s) -
Wang Hongwei,
Li Jingjing,
Lv Ting,
Tu Qingfeng,
Huang Zheng,
Wang Xiuli
Publication year - 2013
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/exd.12132
Subject(s) - hairless , photodynamic therapy , immune system , cancer research , immunohistochemistry , apoptosis , cd8 , cell , medicine , immunology , pathology , chemistry , biochemistry , organic chemistry
The therapeutic effects of 5‐aminolevulinic acid ( ALA )‐mediated photodynamic therapy ( PDT ) on cutaneous squamous cell carcinoma ( SCC ) are not fully understood, and the usefulness of topical PDT in the treatment of SCC is still debatable. The most interesting aspect in SCC PDT is perhaps its potential in inducing antitumor immune responses. In this study, cutaneous SCC s were established by UVB irradiation of hairless mice and treated with multiple ALA PDT . Immunohistochemistry assays showed that ALA PDT could induce quick apoptosis, overexpression of TNF α and marked increases in DC s, CD 4 + and CD 8 + cells in tumor interstitium and subcutaneous connective tissues. However, a complete response was only achieved for small SCC s. The clinical value of ALA PDT ‐induced specific antitumor immune responses in long‐term control of SCC s deserves further study.