Approach towards developing a novel procedure to selectively quantify topically applied substances in the hair follicles of the model tissue porcine ear skin | Zendy

Knorr Fanny | Zendy; Patzelt Alexa | Zendy; Richter Heike | Zendy; Schanzer Sabine | Zendy; Sterry Wolfram | Zendy; Lademann Juergen | Zendy

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Approach towards developing a novel procedure to selectively quantify topically applied substances in the hair follicles of the model tissue porcine ear skin

Author(s) -

Knorr Fanny,

Patzelt Alexa,

Richter Heike,

Schanzer Sabine,

Sterry Wolfram,

Lademann Juergen

Publication year - 2013

Publication title -

experimental dermatology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.108

H-Index - 96

eISSN - 1600-0625

pISSN - 0906-6705

DOI - 10.1111/exd.12113

Subject(s) - hair follicle , chemistry , dermatology , biomedical engineering , medicine , biology , microbiology and biotechnology

Hair follicles represent reservoirs for localized drug therapy and transport pathways for systemic drug delivery. This study describes an approach towards developing a novel procedure for quantifying topically applied substances located in the hair follicles of porcine ear skin, a model for human in vivo skin, using a fluorescent dye. Approximately 5% of the topically applied dye was recovered from the hair follicles, which is in accordance with a previous study.

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