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Functional melanocortin 1 receptor M c1r is not necessary for an inflammatory response to UV radiation in adult mouse skin
Author(s) -
WolnickaGlubisz Agnieszka,
Fabo Edward,
Noonan Frances
Publication year - 2013
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/exd.12100
Subject(s) - melanocortin 1 receptor , immunosuppression , immune system , inflammation , receptor , inflammatory response , dna damage , chemistry , immunology , microbiology and biotechnology , biology , dna , biochemistry , gene , allele
The G ‐protein‐coupled receptor, M c1r, plays a major role in pigment production and has been reported to be important in the inflammatory response. We have investigated the effect of deficiency in M c1r on UV ‐induced inflammation. Mice on the same genetic background were used – C 57 BL /6‐c (albino), C 57 BL /6 (black), C 57 BL /6‐ M c1r e/e deficient (yellow). FACS analysis of disaggregated skin showed a similar dose‐dependent increase in L y6 G + and CD 11b + cells in response to UV radiation in all groups. No differences in UV ‐induced edema or in DNA damage were detected between groups. The contact hypersensitivity response, neonatal immune tolerance and UV immunosuppression were all similar in C 57 BL /6 and C 57 BL /6‐ M c1r e/e mice. We conclude that the absence of M c1r does not impair the inflammatory response to UV radiation or the generation of immunosuppression.