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Genetic alterations in RAS ‐regulated pathway in acral lentiginous melanoma
Author(s) -
PuigButillé Joan A.,
Badenas Celia,
Ogbah Zighereda,
Carrera Cristina,
Aguilera Paula,
Malvehy Josep,
Puig Susana
Publication year - 2013
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/exd.12080
Subject(s) - acral lentiginous melanoma , melanoma , biology , dermatology , medicine , cancer research
Studies integrating clinicopathological and genetic features have revealed distinct patterns of genomic aberrations in M elanoma. Distributions of BRAF or NRAS mutations and gains of several oncogenes differ among melanoma subgroups, while 9p21 deletions are found in all melanoma subtypes. In the study, status of genes involved in cell cycle progression and apoptosis was evaluated in a panel of 17 frozen primary acral melanomas. NRAS mutations were found in 17% of the tumors. In contrast, BRAF mutations were not found. Gains of AURKA gene (20q13.3) were detected in 37.5% of samples, gains of CCND1 gene (11q13) or TERT gene (5p15.33) in 31.2% and gains of NRAS gene (1p13.2) in 25%. Alterations in 9p21 were identified in 69% of tumors. Gains of 11q13 and 20q13 were mutually exclusive, and 1p13.2 gain was associated with 5p15.33. Our findings showed that alterations in RAS ‐related pathways are present in 87.5% of acral lentiginous melanomas.