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Galanin is a modulator of eccrine sweat gland secretion
Author(s) -
Bovell Douglas L.,
Holub Barbara S.,
Odusanwo Olutayo,
Brodowicz Bernhard,
Rauch Isabella,
Kofler Barbara,
Lang Roland
Publication year - 2013
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/exd.12067
Subject(s) - galanin , endocrinology , medicine , sweat gland , neuropeptide , antagonist , secretion , chemistry , receptor , eccrine sweat gland , galanin receptor , sweat , biology
The neuropeptide galanin has been ascribed different roles in modulating physiological functions in the skin. The present study examined the function of galanin in eccrine sweat gland physiology. We demonstrated secretion of galanin by sweat glands in vivo by radioimmunoassay of human sweat (20–192 fmol galanin/ml). Furthermore, human sweat glands expressed galanin receptors G al R 2 and G al R 3. Using chamber short‐circuit current ( I sc) measurements showed that application of galanin to human NCL ‐ SG 3 cells led to a significant increase in I sc, which was inhibited by the presence of chloride channel blockers and in chloride‐free K rebs solution. Additionally, application of SNAP 37889, a non‐peptidergic selective antagonist of G al R 3, abolished the effect of galanin on I sc. In summary, our results show that galanin can regulate transepithelial chloride ion transport and fluid secretion by stimulating G al R 3 in NCL ‐ SG 3 cells and demonstrate a possible important extraneural function of galanin in sweat gland physiology.