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The effects of S ophora angustifolia and other natural plant extracts on melanogenesis and melanin transfer in human skin cells
Author(s) -
Singh Suman K.,
Baker Richard,
Wibawa Judata I. D.,
Bell Mike,
Tobin Desmond J.
Publication year - 2013
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/exd.12061
Subject(s) - melanin , niacinamide , filopodia , skin whitening , tyrosinase , human skin , epidermis (zoology) , microphthalmia associated transcription factor , melanocyte , chemistry , arbutin , phototype , melanoma , biochemistry , biology , dermatology , cancer research , pharmacology , nicotinamide , medicine , anatomy , cell , genetics , active ingredient , enzyme
Skin pigmentation is a multistep process of melanin synthesis by melanocytes, its transfer to recipient keratinocytes and its degradation. As dyspigmentation is a prominent marker of skin ageing, novel effective agents that modulate pigmentation safely are being sought for both clinical and cosmetic use. Here, a number of plant extracts were examined for their effect on melanogenesis (by melanin assay and W estern blotting) and melanin transfer (by confocal immunomicroscopy of gp100‐positive melanin granules in cocultures and by SEM analysis of filopodia), in human melanocytes and in cocultures with phototype‐matched normal adult epidermal keratinocytes. M ulberry, K iwi and S ophora extracts were assessed against isobutylmethylxanthine, hydroquinone, vitamin C and niacinamide. Compared with unstimulated control, all extracts significantly reduced melanogenesis in human melanoma cells and normal adult epidermal melanocytes. These extracts also reduced melanin transfer and reduced filopodia expression on melanocytes, similar to hydroquinone and niacinamide, indicating their effectiveness as multimode pigmentation actives.