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Spontaneous occurrence of photoageing‐like phenotypes in the dorsal skin of old SAMP 1 mice, an oxidative stress model
Author(s) -
Sakura Masaaki,
Chiba Yoichi,
Kamiya Emi,
Furukawa Ayako,
Kawamura Noriko,
Niwa Masanao,
Takeuchi Minoru,
Hosokawa Masanori
Publication year - 2013
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/exd.12059
Subject(s) - hairless , oxidative stress , senescence , proinflammatory cytokine , pathogenesis , downregulation and upregulation , skin aging , chemistry , biology , immunology , microbiology and biotechnology , endocrinology , inflammation , medicine , biochemistry , dermatology , gene
Skin photoageing is a complex, multifactorial process and both intrinsic and extrinsic factors may contribute to its pathogenesis. The ultraviolet‐irradiated hairless mouse has been used as an animal model for photoageing, but this model mimics only the ‘extrinsic’ aspects. Here, we show that skin from old SAMP 1 mice, a model for higher oxidative stress and senescence acceleration, exhibited histological and gene expression changes similar to those in human photoaged skin without ultraviolet irradiation. These changes include an increase in elastic fibre and glycosaminoglycan histologically, an upregulation of several proinflammatory cytokines and matrix metalloproteinases, and an increase in lipid peroxide. We propose that SAMP 1 mice are a spontaneous animal model for photoageing caused by an exaggerated intrinsic mechanism, namely, higher oxidative status. This mouse model is useful to explore the link between oxidative stress and photoageing, and to evaluate the efficacy of antioxidants.