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The guardians of inherited oncogenic vulnerabilities
Author(s) -
Arnal Audrey,
Tissot Tazzio,
Ujvari Beata,
Nunney Leonard,
Solary Eric,
Laplane Lucie,
Bonhomme François,
Vittecoq Marion,
Tasiemski Aurélie,
Renaud François,
Pujol Pascal,
Roche Benjamin,
Thomas Frédéric
Publication year - 2016
Publication title -
evolution
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.84
H-Index - 199
eISSN - 1558-5646
pISSN - 0014-3820
DOI - 10.1111/evo.12809
Subject(s) - biology , pleiotropy , natural selection , genetic fitness , selection (genetic algorithm) , allele , genetics , mutation accumulation , inclusive fitness , evolutionary biology , gene , phenotype , mutation rate , artificial intelligence , computer science
Similar to seemingly maladaptive genes in general, the persistence of inherited cancer‐causing mutant alleles in populations remains a challenging question for evolutionary biologists. In addition to traditional explanations such as senescence or antagonistic pleiotropy, here we put forward a new hypothesis to explain the retention of oncogenic mutations. We propose that although natural defenses evolve to prevent neoplasm formation and progression thus increasing organismal fitness, they also conceal the effects of cancer‐causing mutant alleles on fitness and concomitantly protect inherited ones from purging by purifying selection. We also argue for the importance of the ecological contexts experienced by individuals and/or species. These contexts determine the locally predominant fitness‐reducing risks, and hence can aid the prediction of how natural selection will influence cancer outcomes.