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SHIFTING FITNESS LANDSCAPES IN RESPONSE TO ALTERED ENVIRONMENTS
Author(s) -
Hietpas Ryan T.,
Bank Claudia,
Jensen Jeffrey D.,
Bolon Daniel N. A.
Publication year - 2013
Publication title -
evolution
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.84
H-Index - 199
eISSN - 1558-5646
pISSN - 0014-3820
DOI - 10.1111/evo.12207
Subject(s) - biology , adaptation (eye) , adaptive evolution , fitness landscape , experimental evolution , genetic fitness , evolutionary biology , saccharomyces cerevisiae , local adaptation , point mutation , mutation , ecology , genetics , biological evolution , gene , demography , neuroscience , population , sociology
The role of adaptation in molecular evolution has been contentious for decades. Here, we shed light on the adaptive potential in Saccharomyces cerevisiae by presenting systematic fitness measurements for all possible point mutations in a region of Hsp90 under four environmental conditions. Under elevated salinity, we observe numerous beneficial mutations with growth advantages up to 7% relative to the wild type. All of these beneficial mutations were observed to be associated with high costs of adaptation. We thus demonstrate that an essential protein can harbor adaptive potential upon an environmental challenge, and report a remarkable fit of the data to a version of Fisher's geometric model that focuses on the fitness trade‐offs between mutations in different environments.