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Antimicrobial resistance in bacteria isolated from diseased horses in France
Author(s) -
Bourély C.,
Cazeau G.,
Jarrige N.,
Haenni M.,
Gay E.,
Leblond A.
Publication year - 2020
Publication title -
equine veterinary journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.82
H-Index - 87
eISSN - 2042-3306
pISSN - 0425-1644
DOI - 10.1111/evj.13133
Subject(s) - antibiotic resistance , microbiology and biotechnology , trimethoprim , sulfamethoxazole , staphylococcus aureus , gentamicin , biology , antimicrobial , klebsiella , multiple drug resistance , tetracycline , veterinary medicine , bacteria , drug resistance , antibiotics , escherichia coli , medicine , biochemistry , genetics , gene
Summary Background Horses are one of the potential reservoirs of antimicrobial resistance ( AMR ) determinants that could be transferred to human subjects. Objective To describe the AMR patterns of major bacteria isolated from diseased horses in France. Study design Retrospective observational study. Methods Data collected between 2012 and 2016 by RESAPATH , the French national surveillance network for AMR , were analysed. Only antimicrobials relevant in veterinary and human medicine for the isolated bacteria were considered. Mono‐ and multidrug resistance were calculated. The resistance proportions of major equine diseases were assessed and compared. Where data permitted, resistance trends were investigated using nonlinear analysis (generalised additive models). Results A total of 12,695 antibiograms were analysed. The five most frequently isolated bacteria were Streptococcus spp., Escherichia coli , Pseudomonas spp., Staphylococcus aureus , Pantoea spp. and Klebsiella spp. The highest proportions of resistance to gentamicin were found for S. aureus (22.1%) and Pseudomonas spp. (26.9%). Klebsiella spp. and E. coli had the highest proportions of resistance to trimethoprim‐sulfamethoxazole (15.5 and 26.2%, respectively). Proportions of resistance to tetracycline were among the highest for all the bacteria considered. Resistance to third‐generation cephalosporins was below 10% for all Enterobacteriaceae . The highest proportions of multidrug resistance (22.5%) were found among S. aureus isolates, which is worrying given their zoonotic potential. From 2012 to 2016, resistance proportions decreased in Pseudomonas spp. isolates, but remained the same for S. aureus . For Streptococcus spp. and E. coli , resistance proportions to trimethoprim‐sulfamethoxazole increased. Main limitations Since antibiograms are not systematic analyses, any selection bias could impact the results. Conclusions Such studies are essential to estimate the magnitude of the potential threat of AMR to public health, to design efficient control strategies and to measure their effectiveness. These findings may also guide the initial empirical treatment of horse diseases.