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Equus caballus papillomavirus 8 (Ec PV 8) associated with multiple viral plaques, viral papillomas, and squamous cell carcinoma in a horse
Author(s) -
PetersKennedy J.,
Lange C. E.,
Rine S. L.,
Hackett R. P.
Publication year - 2019
Publication title -
equine veterinary journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.82
H-Index - 87
eISSN - 2042-3306
pISSN - 0425-1644
DOI - 10.1111/evj.13046
Subject(s) - horse , context (archaeology) , bovine papillomavirus , pathology , equus , histopathology , virus , medicine , basal cell , virology , biology , gene , paleontology , zoology , genome , biochemistry
Summary Background Equus caballus papillomavirus 8, a recently discovered virus, has been reported to cause generalised papillomavirus in horses. Objectives To describe a case in which multiple viral plaques, viral papillomas, squamous cell carcinoma ( SCC ) in situ and invasive squamous cell carcinoma ( ISCC ) were associated with Ec PV 8 in a horse. Study design Case report. Methods A 16‐year‐old mixed breed horse presented with dozens of raised crusted papular to nodular lesions over a course of 4 years. Masses had been surgically excised four times and cisplatin beads and emulsion were implanted on three different occasions; however new masses continue to develop in sites of previous masses as well as new sites. Results Multiple viral plaques, viral papillomas, SCC in situ and ISCC , localised to the inguinal region, were diagnosed via histopathology. Ec PV 8 DNA was detected via PCR . Main limitations Since only a few cases have been reported, we do not know the incidence of Ec PV 8 nor how often it may be associated with SCC in situ or ISCC without further study. Conclusions This is the fourth reported case of viral papillomatosis in the context of an Ec PV 8 infection in a horse. This is the first case in which SCC has been associated with Ec PV 8.