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Equine Grass Sickness in S cotland: A Case–Control Study of Environmental Geochemical Risk Factors
Author(s) -
Wylie C.E.,
Shaw D.J.,
Fordyce F.M.,
Lilly A.,
McGorum B.C.
Publication year - 2014
Publication title -
equine veterinary journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.82
H-Index - 87
eISSN - 2042-3306
pISSN - 0425-1644
DOI - 10.1111/evj.12323_48
Subject(s) - conditional logistic regression , logistic regression , distribution (mathematics) , hydrology (agriculture) , environmental science , physical geography , geology , geography , odds ratio , medicine , mathematics , mathematical analysis , geotechnical engineering
Reasons for performing study Epidemiological investigations suggest that soil macro‐ and micro‐nutrients may be a trigger for the occurrence of equine grass sickness ( EGS ). However, there is limited information regarding relationships between exposure to geochemical elements and the occurrence of EGS . Objectives To determine whether the geographical distribution of EGS cases referred to the Royal (Dick) School of Veterinary Studies was associated with the presence or absence of particular geochemical elements in the environment. Study design A retrospective time‐matched case–control study. Methods 455 EGS geo‐referenced cases were identified between 1 January 1990 and 1 June 2006. Each case had 2 time‐matched geo‐referenced controls (n = 910). For study purposes, cases or controls originating outwith S cotland were excluded. Environmental concentrations of a range of elements, most with known biological function, were collated from 2 geochemical point datasets and spatially extrapolated giving continuous cover across S cotland: the B ritish Geological Survey ( BGS ) Geochemical Baseline Survey of the Environment ( G ‐ BASE ) stream sediment dataset and the J ames H utton Institute ( JHI ), National Soil Inventory of S cotland ( NSIS ). Data were analysed using multivariable conditional logistic regression. Results Statistically significant associations were obtained between the distribution of EGS cases and (i) higher environmental levels of C a, K , M o, N a, S e and T i, and (ii) lower environmental levels of A l, C d, C o, C r, C u, N i and P b. This study identified no association between EGS cases and the environmental concentrations of B a, G a, F e, M g, M n, P or S r. Conclusions A number of statistically significant associations were identified between EGS cases and element concentrations in the spatially extrapolated stream sediment and soil data. This information will assist future studies on the aetiology of EGS , with further research suggested to focus on those identified significant associations with greatest biological plausibility such as reduced levels of C u and Z n, and higher levels of K and S e. Ethical animal research: Informed client consent was obtained for the use of clinical records. Sources of funding: Part‐funded by The BGS University Funding Initiative. A . L . is funded by the Scottish Government's Rural and Environment Science and Analytical Services Division. C . E . W . is supported by The Margaret Giffen Trust. F . F . is funded by the Natural Environment Research Council ( NERC ). Competing interests: None.