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Serial plasma vasopressin concentration in healthy and hospitalised neonatal foals
Author(s) -
Borchers A.,
Magdesian K. G.,
Schenck P. A.,
Kass P. H.
Publication year - 2014
Publication title -
equine veterinary journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.82
H-Index - 87
eISSN - 2042-3306
pISSN - 0425-1644
DOI - 10.1111/evj.12121
Subject(s) - vasopressin , medicine , sepsis , resuscitation , prospective cohort study , horse , pediatrics , anesthesia , endocrinology , biology , paleontology
Summary Reasons for performing study Vasopressin dysregulation occurs in critically ill human patients and in neonatal foals. Limited data about serial plasma vasopressin dynamics exist in sick neonatal foals. Objectives To evaluate serial plasma arginine vasopressin ( AVP ) concentrations in sick neonatal foals. Study design Prospective, longitudinal clinical study. Methods Plasma samples were collected from 7 healthy and 26 sick foals before and after initial fluid resuscitation and 12, 24, 36, 48 and 96 h after presentation. Foals with a modified sepsis score ≥11 were considered septic. Results Admission AVP was increased in septic foals compared to healthy and to sick, nonseptic foals. There were no significant differences between groups on subsequent days. Nonsurvivors had higher AVP concentrations than survivors. Conclusions Plasma AVP concentrations are higher in septic foals on admission than in healthy and sick nonseptic foals. Higher early plasma AVP concentrations are associated with increased mortality.