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Comparison of glycopyrrolate and atropine in ameliorating the adverse effects of imidocarb dipropionate in horses
Author(s) -
Donnellan C. M. B.,
Page P. C.,
Nurton J. P.,
Berg J. S.,
Guthrie A. J.
Publication year - 2013
Publication title -
equine veterinary journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.82
H-Index - 87
eISSN - 2042-3306
pISSN - 0425-1644
DOI - 10.1111/evj.12032
Subject(s) - glycopyrrolate , atropine , medicine , crossover study , anesthesia , adverse effect , saline , horse , duodenum , ileus , gastroenterology , biology , paleontology , alternative medicine , pathology , placebo
Summary Reasons for performing study Imidocarb, an effective treatment for piroplasmosis, may cause colic and diarrhoea in horses. Atropine and glycopyrrolate are anticholinergics that could reduce the adverse effects of imidocarb. However, atropine and glycopyrrolate inhibit gastrointestinal motility, potentially causing ileus and colic. Objectives To compare glycopyrrolate and atropine in ameliorating the adverse effects of imidocarb dipropionate in horses and to determine the effect of combinations of these drugs on the gastrointestinal tract. Methods A blinded, randomised, crossover study was performed in 8 healthy horses. Each horse received 0.9% saline i.m and i.v. ( CON ), and imidocarb 2.4 mg/kg bwt i.m. with one of 3 treatments i.v.: 0.9% saline ( IMI ), atropine 0.02 mg/kg bwt ( IMATROP ) and glycopyrrolate 0.0025 mg/kg bwt ( IMGLYCO ). Clinical data, gastrointestinal motility via borborygmi and frequency of contractions in the duodenum, caecum and right dorsal colon assessed with transabdominal ultrasound, and faecal data were measured. Results After imidocarb/saline treatment colic and diarrhoea were noted in 3 and 4 horses, respectively, faecal production and defaecation were increased for 3 h and faecal water percentage for 6 h. Colic was noted after atropine treatment in 4 horses, borborygmi and frequency of right dorsal colon contractions were significantly decreased for 2 h 15 min, and faecal production was not significantly different from CON . After glycopyrrolate treatment, colic was seen in one horse, frequency of intestinal contractions and faecal data were not significantly different from CON , and borborygmi was significantly decreased from CON at 1 h 15 min. Conclusions Results of this study suggest that glycopyrrolate is superior to atropine in ameliorating the adverse effects of imidocarb. Potential relevance Glycopyrrolate could be administered with imidocarb in horses with piroplasmosis to reduce the adverse effects of imidocarb.