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Courses for horses: Rethinking the use of proton pump inhibitors in the treatment of equine gastric ulcer syndrome
Author(s) -
Sykes B. W.
Publication year - 2019
Publication title -
equine veterinary education
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.304
H-Index - 31
eISSN - 2042-3292
pISSN - 0957-7734
DOI - 10.1111/eve.12894
Subject(s) - omeprazole , medicine , proton pump inhibitor , horse , pharmacodynamics , gastroenterology , disease , pharmacokinetics , paleontology , biology
Summary Oral omeprazole has been the cornerstone of equine gastric ulcer syndrome ( EGUS ) treatment for nearly 20 years. However, approximately 15–30% of equine squamous gastric disease ( ESGD ) cases and 75% of equine glandular gastric disease ( EGGD ) cases fail to heal within current treatment guidelines. Recently, a number of factors that may affect the efficacy of oral omeprazole have been highlighted and the pharmacodynamics of a number of novel proton pump inhibitors ( PPI s) have been described in the horse. The purpose of this article is to review the factors that affect oral omeprazole efficacy, with the goal of maximising therapeutic response, and the novel PPI s recently described.