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PCR for antigen receptor rearrangement ( PARR ) in equine veterinary medicine
Author(s) -
Hollis A. R.
Publication year - 2019
Publication title -
equine veterinary education
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.304
H-Index - 31
eISSN - 2042-3292
pISSN - 0957-7734
DOI - 10.1111/eve.12857
Subject(s) - medicine , malignancy , antigen , receptor , polymerase chain reaction , pathology , immunology , biology , gene , genetics
Summary PCR for antigen receptor rearrangement ( PARR ) is a technique developed to aid with the assessment of lymphoid malignancies. The technology relies on the assessment of clonality of T or B cells, and there are many pitfalls. One major advantage is that only a small amount of sample is required to detect clonality, and it can be performed on any type of sample, including effusions, formalin‐fixed paraffin‐embedded tissues and cytological samples. However, the risk of both false negative and false positive results means that PARR should not be used to diagnose a lymphoid malignancy in isolation, but that results should be considered in conjunction with a full clinical and clinicopathological assessment.