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Carcinoma of the mammary gland in a mare
Author(s) -
Bussche L.,
Harms C.,
Buckles E. L.,
Whelchel D.,
Brosnahan M.,
Van de Walle G. R.
Publication year - 2017
Publication title -
equine veterinary education
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.304
H-Index - 31
eISSN - 2042-3292
pISSN - 0957-7734
DOI - 10.1111/eve.12500
Subject(s) - mammary gland , vimentin , cytokeratin , medicine , pathology , immunohistochemistry , histopathology , parenchyma , downregulation and upregulation , cancer , horse , carcinoma , breast cancer , biology , gene , paleontology , biochemistry
Summary A 20‐year‐old Quarter Horse mare was presented with a firm, nonpainful swelling near the axial margin of the left mammary gland. Ultrasound examination of the mass revealed a 35 mm poorly encapsulated, homogeneous mass within the parenchyma of the left mammary gland. Using histopathology and immunohistochemistry, the mass was diagnosed as a mammary carcinoma and showed positivity for cytokeratin 18 ( CK 18), vimentin and α‐smooth muscle actin. Additionally, the mRNA expression level of the oncogene cM yc did not show a significant upregulation, whereas p53 , a well‐known tumour suppressor gene in breast cancer, was significantly reduced in comparison with healthy equine mammary gland tissue. To the authors' knowledge, this is the first report of a significant downregulation of p53 expression in a mammary carcinoma of a mare.