Phenylbutazone in horses and man: Properties relevant to safety of humans consuming horse meat containing phenylbutazone and its metabolites | Zendy

Lees P. | Zendy; Toutain P.L. | Zendy

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Phenylbutazone in horses and man: Properties relevant to safety of humans consuming horse meat containing phenylbutazone and its metabolites

Author(s) -

Lees P.,

Toutain P.L.

Publication year - 2013

Publication title -

equine veterinary education

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.304

H-Index - 31

eISSN - 2042-3292

pISSN - 0957-7734

DOI - 10.1111/eve.12112

Subject(s) - phenylbutazone , horse , pharmacology , medicine , cyclooxygenase , donkey , prostaglandin e2 , equidae , inflammation , chemistry , biochemistry , enzyme , biology , paleontology , ecology

This editorial assesses the potential toxicity for human individuals consuming equine muscle containing phenylbutazone and its metabolites, in trace amounts, by reviewing: 1) the pharmacokinetic, pharmacodynamic, metabolic and toxicological profiles of phenylbutazone in horses and man; 2) phenylbutazone residues in equine muscle; 3) the extent of consumption of equine meat, containing phenylbutazone or not; and 4) the moves being made towards improving the equine passport system. This editorial summarises and extends the contents of a recent review (Lees and Toutain 2013).

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