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Pancytopenia in two horses following administration of potentiated sulfonamide antimicrobials
Author(s) -
Cudmore L.,
Jalim S.,
Williamson M. M.,
McKin A. O.
Publication year - 2015
Publication title -
equine veterinary education
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.304
H-Index - 31
eISSN - 2042-3292
pISSN - 0957-7734
DOI - 10.1111/eve.12000
Subject(s) - medicine , pancytopenia , sulfonamide , antimicrobial , sulfadimidine , bone marrow aplasia , drug , sulfadimethoxine , trimethoprim , pharmacology , adverse effect , sulfisoxazole , antibiotics , bone marrow , immunology , microbiology and biotechnology , tetracycline , biology , stereochemistry , chemistry , chromatography
Summary Adverse drug reactions to potentiated sulfonamide antimicrobial drug combinations have been reported in many species, including horses. This report describes the occurrence of pancytopenia in 2 horses, one subsequent to an immune mediated reaction and the other bone marrow aplasia following the administration of trimethoprim and sulfadimidine. These cases highlight the importance of judicious use of antimicrobial agents and describe adverse drug reactions in horses receiving potentiated sulfonamide antimicrobials.