Premium
The Effect of Omeprazole on the Microbiota of Healthy Adult Horses
Author(s) -
Debra Archer,
Michelle Barton,
Tim Mair
Publication year - 2017
Publication title -
equine veterinary education
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.304
H-Index - 31
eISSN - 2042-3292
pISSN - 0957-7734
DOI - 10.1111/eve.07_12792
Subject(s) - omeprazole , medicine , horse , physiology , gastroenterology , biology , paleontology
Tyma J.F., Epstein K.L., Whitfield C.M., Cohen N.D. and Gigu ere S. Department of Large Animal Medicine, University of Georgia, Veterinary Medical Center, 2200 College Station Road, Athens, GA 30602, USA. E-mail: jft31319@uga.edu. Background: Equine gastric ulcer syndrome (EGUS) is a multifactorial disease of high prevalence in horses. The treatment of choice for EGUS is omeprazole, a proton pump inhibitor available as a proprietary oral formulation. Empirical administration of omeprazole without diagnostic evidence of gastric disease is commonplace in equine practice. In people, proton pump inhibitors have been associated with the development of infectious gastrointestinal complications and a shift in gastrointestinal microflora. An increase in the incidence of diarrhea has been reported in foals treated with proton pump inhibitors. Novel sequencing technologies have allowed indepth analysis of broad microbial communities, including those present in the gastrointestinal tract.