Open AccessOn the need for integrating cancer into the One Health perspective
Author(s) -
Dujon Antoine,
Brown Joel S.,
DestoumieuxGarzón Delphine,
Vittecoq Marion,
Hamede Rodrigo,
Tasiemski Aurélie,
Boutry Justine,
Tissot Sophie,
AlixPanabieres Catherine,
Pujol Pascal,
Renaud François,
Simard Frédéric,
Roche Benjamin,
Ujvari Beata,
Thomas Frédéric
Publication year - 2021
Publication title -
evolutionary applications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.776
H-Index - 68
ISSN - 1752-4571
DOI - 10.1111/eva.13303
Subject(s) - biology , pandemic , wildlife , human health , one health , perspective (graphical) , cancer , disease , ecology , environmental ethics , covid-19 , public health , infectious disease (medical specialty) , environmental health , genetics , medicine , nursing , artificial intelligence , computer science , philosophy , pathology
Summary Recent pandemics have highlighted the urgency to connect disciplines studying animal, human, and environment health, that is, the “One Health” concept. The One Health approach takes a holistic view of health, but it has largely focused on zoonotic diseases while not addressing oncogenic processes. We argue that cancers should be an additional key focus in the One Health approach based on three factors that add to the well‐documented impact of humans on the natural environment and its implications on cancer emergence. First, human activities are oncogenic to other animals, exacerbating the dynamics of oncogenesis, causing immunosuppressive disorders in wildlife with effects on host–pathogen interactions, and eventually facilitating pathogen spillovers. Second, the emergence of transmissible cancers in animal species (including humans) has the potential to accelerate biodiversity loss across ecosystems and to become pandemic. It is crucial to understand why, how, and when transmissible cancers emerge and spread. Third, translating knowledge of tumor suppressor mechanisms found across the Animal Kingdom to human health offers novel insights into cancer prevention and treatment strategies.