z-logo
open-access-imgOpen Access
An evolutionary explanation for the presence of cancer nonstem cells in neoplasms
Author(s) -
Sprouffske Kathleen,
Athena Aktipis C.,
Radich Jerald P.,
Carroll Martin,
Nedelcu Aurora M.,
Maley Carlo C.
Publication year - 2013
Publication title -
evolutionary applications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.776
H-Index - 68
ISSN - 1752-4571
DOI - 10.1111/eva.12030
Subject(s) - biology , multicellular organism , cancer stem cell , cancer cell , cancer , stem cell , somatic evolution in cancer , evolutionary dynamics , evolutionary biology , cell , genetics , population , demography , sociology
Contrary to conventional views that assume all cells in a neoplasm can propagate the tumor, the cancer stem cell hypothesis posits that only a fraction of the cells (the cancer stem cells) can act as tumor‐propagating cells, while most of the tumor is composed of cells with limited replication potential. Here, we offer an evolutionary approach to this controversy. We used several evolutionary, computational models to investigate cancer cell dynamics and conditions consistent with the stem cell hypothesis. Our models predict that if selection acts at the cell level, neoplasms should be primarily comprised of cancer stem cells, in contrast to experimental data indicating that neoplasms contain large fractions of cancer nonstem cells. We explore several solutions explaining the paradoxical existence of cancer nonstem cells in neoplasms, including the possibility that selection acts at the level of multicellular proliferative units.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.
Having issues? You can contact us here