Open AccessAssociation mapping of genetic risk factors for chronic wasting disease in wild deer
Author(s) -
Matsumoto Tomomi,
Samuel Michael D.,
Bollinger Trent,
Pybus Margo,
Coltman David W.
Publication year - 2013
Publication title -
evolutionary applications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.776
H-Index - 68
ISSN - 1752-4571
DOI - 10.1111/eva.12003
Subject(s) - chronic wasting disease , odocoileus , biology , linkage disequilibrium , microsatellite , genetics , genetic association , single nucleotide polymorphism , zoology , disease , genotype , gene , allele , prion protein , medicine , scrapie
Chronic wasting disease ( CWD ) is a fatal transmissible spongiform encephalopathy affecting North American cervids. We assessed the feasibility of association mapping CWD genetic risk factors in wild white‐tailed deer ( O docoileus virginianus ) and mule deer ( O docoileus hemionus ) using a panel of bovine microsatellite markers from three homologous deer linkage groups predicted to contain candidate genes. These markers had a low cross‐species amplification rate (27.9%) and showed weak linkage disequilibrium (<1 c M ). Markers near the prion protein and the neurofibromin 1 ( NF 1 ) genes were suggestively associated with CWD status in white‐tailed deer ( P = 0.006) and mule deer ( P = 0.02), respectively. This is the first time an association between the NF 1 region and CWD has been reported.