Association mapping of genetic risk factors for chronic wasting disease in wild deer | Zendy

Matsumoto Tomomi | Zendy; Samuel Michael D. | Zendy; Bollinger Trent | Zendy; Pybus Margo | Zendy; Coltman David W. | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Association mapping of genetic risk factors for chronic wasting disease in wild deer

Author(s) -

Matsumoto Tomomi,

Samuel Michael D.,

Bollinger Trent,

Pybus Margo,

Coltman David W.

Publication year - 2013

Publication title -

evolutionary applications

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.776

H-Index - 68

ISSN - 1752-4571

DOI - 10.1111/eva.12003

Subject(s) - chronic wasting disease , odocoileus , biology , linkage disequilibrium , microsatellite , genetics , genetic association , single nucleotide polymorphism , zoology , disease , genotype , gene , allele , prion protein , medicine , scrapie

Chronic wasting disease ( CWD ) is a fatal transmissible spongiform encephalopathy affecting North American cervids. We assessed the feasibility of association mapping CWD genetic risk factors in wild white‐tailed deer ( O docoileus virginianus ) and mule deer ( O docoileus hemionus ) using a panel of bovine microsatellite markers from three homologous deer linkage groups predicted to contain candidate genes. These markers had a low cross‐species amplification rate (27.9%) and showed weak linkage disequilibrium (<1 c M ). Markers near the prion protein and the neurofibromin 1 ( NF 1 ) genes were suggestively associated with CWD status in white‐tailed deer ( P = 0.006) and mule deer ( P = 0.02), respectively. This is the first time an association between the NF 1 region and CWD has been reported.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research