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The probability of seizures during continuous EEG monitoring in high‐risk neonates
Author(s) -
Worden Lila T.,
Chinappen Dhinakaran M.,
Stoyell Sally M.,
Gold Jacquelyn,
Paixao Luis,
Krishnamoorthy Kalpathy,
Kramer Mark A.,
Westover Michael B.,
Chu Catherine J.
Publication year - 2019
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/epi.16387
Subject(s) - electroencephalography , hazard ratio , medicine , epilepsy , discontinuation , proportional hazards model , neonatal seizure , confidence interval , anesthesia , encephalopathy , pediatrics , psychiatry
Objective We evaluated the impact of monitoring indication, early electroencephalography (EEG), and clinical features on seizure risk in all neonates undergoing continuous EEG (cEEG) monitoring following a standardized monitoring protocol. Methods All cEEGs from unique neonates 34‐48 weeks postmenstrual age monitored from 1/2011‐10/2017 (n = 291) were included. We evaluated the impact of cEEG monitoring indication (acute neonatal encephalopathy [ANE], suspicious clinical events [SCEs], or other high‐risk conditions [OHRs]), age, medication status, and early EEG abnormalities (including the presence of epileptiform discharges and abnormal background continuity, amplitude, asymmetry, asynchrony, excessive sharp transients, and burst suppression) on time to first seizure and overall seizure risk using Kaplan‐Meier survival curves and multivariable Cox proportional hazards models. Results Seizures occurred in 28% of high‐risk neonates. Discontinuation of monitoring after 24 hours of seizure‐freedom would have missed 8.5% of neonates with seizures. Overall seizure risk was lower in neonates monitored for ANE compared to OHR ( P  = .004) and trended lower compared to SCE ( P  = .097). The time course of seizure presentation varied by group, where the probability of future seizure was less than 1% after 17 hours of seizure‐free monitoring in the SCE group, but required 42 hours in the OHR group, and 73 hours in the ANE group. The presence of early epileptiform discharges increased seizure risk in each group (ANE: adjusted hazard ratio [aHR] 4.32, 95% confidence interval [CI] 1.23‐15.13, P  = .022; SCE: aHR 10.95, 95% CI 4.77‐25.14, P  < 1e‐07; OHR: aHR 56.90, 95% CI 10.32‐313.72, P  < 1e‐05). Significance Neonates who undergo cEEG are at high risk for seizures, and risk varies by monitoring indication and early EEG findings. Seizures are captured in nearly all neonates undergoing monitoring for SCE within 24 hours of cEEG monitoring. Neonates monitored for OHR and ANE can present with delayed seizures and require longer durations of monitoring. Early epileptiform discharges are the best early EEG feature to predict seizure risk.

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