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Illness severity scoring in status epilepticus—When STESS meets APACHE II , SAPS II , and SOFA
Author(s) -
Semmlack Saskia,
Kaplan Peter W.,
Spiegel Rainer,
De Marchis Gian Marco,
Hunziker Sabina,
Tisljar Kai,
Rüegg Stephan,
Marsch Stephan,
Sutter Raoul
Publication year - 2019
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/epi.14623
Subject(s) - medicine , glasgow coma scale , confidence interval , odds ratio , logistic regression , severity of illness , status epilepticus , cohort , prospective cohort study , intensive care unit , receiver operating characteristic , sofa score , saps ii , apache ii , intensive care , cohort study , intensive care medicine , surgery , epilepsy , psychiatry
Summary Objective To characterize a critically ill cohort with status epilepticus ( SE ) by the illness severity scoring systems SAPS II (Simplified Acute Physiology Score II), APACHE II (Acute Physiology and Chronic Health Evaluation II), and SOFA (Sequential Organ Failure Assessment), and to compare their performance with the STESS (Status Epilepticus Severity Score) for outcome prediction. Methods The prospective cohort study was carried out at the University Hospital Basel, a Swiss tertiary academic medical care center. Consecutive adult SE patients hospitalized in the intensive care units from 2011 to 2016 were included. Illness severity scores and additional clinical data were recorded. Logistic regression models using automated variable selection were applied to identify scores associated with no return to functional and neurological baseline and death. Measures of discrimination and calibration were assessed. Results Among 184 patients, 33% returned to baseline. Median scores of the illness severity scores were within the lowest third of the possible scoring ranges, and all differed significantly between patients with and without return to baseline. The areas under the receiver operating curves for the prediction of no return to baseline and death ranged from 0.64 to 0.73, with the highest value for the STESS predicting no return to baseline. Measures of calibration revealed adequate model fit for all analyses. Among integral components of the scoring systems, only the Glasgow Coma Scale (GCS) differed significantly between patients with and without return to baseline. In multivariable analyses, decreasing GCS and increasing STESS had the strongest associations (odds ratio [ OR ] = 0.84, 95% confidence interval [ CI ] = 0.77‐0.93 and OR = 1.34, 95% CI = 1.05‐1.68, respectively) with no return to baseline independent of all other scoring systems, whereas the APACHE II revealed the strongest association with death ( OR = 1.15, 95% CI = 1.06‐1.25). Significance Although complex illness severity scoring systems in SE patients facilitate benchmarking and comparisons with other severely ill patient cohorts, they offer no advantages over the STESS and GCS regarding prediction of no return to baseline.