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Quantitative positron emission tomography –guided magnetic resonance imaging postprocessing in magnetic resonance imaging–negative epilepsies
Author(s) -
Lin Yicong,
Fang YuHua Dean,
Wu Guiyun,
Jones Stephen E.,
Prayson Richard A.,
Moosa Ahsan N. V.,
Overmyer Margit,
Bena James,
Larvie Mykol,
Bingaman William,
GonzalezMartinez Jorge A.,
Najm Imad M.,
Alexopoulos Andreas V.,
Wang Z. Irene
Publication year - 2018
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/epi.14474
Subject(s) - magnetic resonance imaging , medicine , nuclear medicine , concordance , positron emission tomography , cortical dysplasia , radiology , epilepsy surgery , epilepsy , psychiatry
Summary Objective Detection of focal cortical dysplasia ( FCD ) is of paramount importance in epilepsy presurgical evaluation. Our study aims at utilizing quantitative positron emission tomography ( QPET ) analysis to complement magnetic resonance imaging ( MRI ) postprocessing by a morphometric analysis program ( MAP ) to facilitate automated identification of subtle FCD . Methods We retrospectively included a consecutive cohort of surgical patients who had a negative preoperative MRI by radiology report. MAP was performed on T1‐weighted volumetric sequence and QPET was performed on PET /computed tomographic data, both with comparison to scanner‐specific normal databases. Concordance between MAP and QPET was assessed at a lobar level, and the significance of concordant QPET ‐ MAP + abnormalities was confirmed by postresective seizure outcome and histopathology. QPET thresholds of standard deviations ( SDs ) of −1, −2, −3, and −4 were evaluated to identify the optimal threshold for QPET ‐ MAP analysis. Results A total of 104 patients were included. When QPET thresholds of SD = −1, −2, and −3 were used, complete resection of the QPET ‐ MAP + region was significantly associated with seizure‐free outcome when compared with the partial resection group ( P = 0.023, P < 0.001, P = 0.006) or the no resection group ( P = 0.002, P < 0.001, P = 0.001). The SD threshold of −2 showed the best combination of positive rate (55%), sensitivity (0.68), specificity (0.88), positive predictive value (0.88), and negative predictive value (0.69). Surgical pathology of the resected QPET ‐ MAP + areas revealed mainly FCD type I. Multiple QPET ‐ MAP + regions were present in 12% of the patients at SD = −2. Significance Our study demonstrates a practical and effective approach to combine quantitative analyses of functional ( QPET ) and structural ( MAP ) imaging data to improve identification of subtle epileptic abnormalities. This approach can be readily adopted by epilepsy centers to improve postresective seizure outcomes for patients without apparent lesions on MRI .