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Altered vaccine‐induced immunity in children with Dravet syndrome
Author(s) -
Auvin Stéphane,
Jeljeli Mohamed,
Desnous Béatrice,
SoussiYanicostas Nadia,
Dournaud Pascal,
Sterkers Ghislaine
Publication year - 2018
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/epi.14038
Subject(s) - dravet syndrome , immunology , medicine , ex vivo , immune system , vaccination , peripheral blood mononuclear cell , cytokine , epilepsy , proinflammatory cytokine , epilepsy syndromes , in vivo , biology , inflammation , in vitro , biochemistry , microbiology and biotechnology , psychiatry
Summary Dravet syndrome ( DS ) is a refractory epileptic syndrome. Vaccination is the trigger of the first seizure in about 50% of cases. Fever remains a trigger of seizures during the course of the disease. We compared ex vivo cytokine responses to a combined aluminium‐adjuvanted vaccine of children with DS to sex‐ and age‐matched heathy children. Using ex vivo cytokine responses of peripheral‐blood mononuclear cells and monocytes, we found that vaccine responsiveness is biased toward a proinflammatory profile in DS with a M1 phenotype of monocytes. We provide new insight into immune mechanisms associated with DS that might guide research for the development of new immunotherapeutic agents in this epilepsy syndrome.