Premium
Health care resource utilization before and after perampanel initiation among patients with epilepsy in the United States
Author(s) -
Faught Edward,
Laliberté François,
Wang Zhixiao,
Barghout Victoria,
Haider Batool,
Lejeune Dominique,
Germain Guillaume,
Choi Jiyoon,
Wagh Aneesha,
Duh Mei Sheng
Publication year - 2017
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/epi.13857
Subject(s) - perampanel , epilepsy , medicine , pediatrics , diagnosis code , health care , psychiatry , population , environmental health , economics , economic growth
Summary Objective The purpose of this study was to evaluate changes in health care resource utilization following the initiation of perampanel for the treatment of epilepsy in the United States . Methods Health care claims from Symphony Health's Integrated Dataverse database between December 2012 and November 2015 were analyzed. Patients newly initiated on perampanel, having ≥1 epilepsy (International Classification of Diseases, Ninth Revision, Clinical Modification [ICD‐9‐CM] code 345.xx, ICD ‐10‐ CM code G40.xxx) or nonfebrile convulsion ( ICD ‐9‐ CM code 780.39, ICD ‐10‐ CM code R56.9) diagnosis, and having ≥6 months of baseline and observation periods were included. Patients <12 years old at perampanel initiation were excluded. Results Of the 2,508 perampanel patients included in the study, the mean [median] (±standard deviation [ SD ]) age was 35.8 [34] (±16.0) years and 56.2% were female. The mean [median] (± SD ) observation duration was 459.8 [462] (±146.3) days in the postperampanel period. The postperampanel period was associated with significantly lower rates of all health care resource utilization outcomes than the pre‐period. For the post‐ versus pre‐period, perampanel users had 42.3 versus 53.8 overall hospitalizations per 100 person‐years (rate ratio [ RR ] = 0.80, p < 0.001) and 1,240.2 versus 1,343.8 outpatient visits per 100 person‐years ( RR = 0.91, p < 0.001). Epilepsy‐related hospitalizations and outpatient visits were 25.2 versus 33.6 per 100 person‐years ( RR = 0.76, p < 0.001) and 327.0 versus 389.0 per 100 person‐years ( RR = 0.84, p < 0.001), respectively. Additionally, a significantly lower rate of status epilepticus in the post‐period (1.8 events per 100 person‐years) was observed compared to the pre‐period (4.4 events per 100 person‐years; RR = 0.43, p < 0.001). The monthly time trend of hospitalizations showed an increasing trend leading up to the initiation of perampanel, after which the hospitalizations decreased steadily. Significance Use of perampanel for the treatment of epilepsy was associated with significant reduction in all‐cause and epilepsy‐related health care resource utilization, including hospitalizations, especially for status epilepticus, and outpatient visits.