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Increased susceptibility to pentylenetetrazol following survival of cerebral malaria in mice
Author(s) -
Grauncke Ana C. B.,
Souza Thaíze L.,
Ribeiro Leandro R.,
Brant Fátima,
Machado Fabiana S.,
Oliveira Mauro S.
Publication year - 2016
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/epi.13425
Subject(s) - pentylenetetrazol , plasmodium berghei , malaria , cerebral malaria , epilepsy , medicine , electroencephalography , anesthesia , tonic (physiology) , immunology , plasmodium falciparum , anticonvulsant , psychiatry
Summary Malaria is considered a neglected disease and public health problem, affecting >200 million people worldwide. In the present study we used the Plasmodium berghei ANKA (PbA) model of experimental cerebral malaria ( CM ) in C57 BL /6 mice. After rescue from CM and parasite clearance, animals were submitted to a seizure susceptibility test (45 days after infection) using a low dose of pentylenetetrazol ( PTZ , 30 mg/kg) and monitored with use of behavioral and electroencephalography (EEG) methods. Mice rescued from CM presented a reduced latency to myoclonic and tonic–clonic seizures and an increased duration of tonic–clonic seizures. In addition, quantitative analysis of EEG revealed a decrease in relative power at beta frequency band in PbA‐infected animals after PTZ injection. Our results suggest that CM may lead to increased susceptibility to seizures in mice.