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Status epilepticus in scrub typhus
Author(s) -
Kalita Jayantee,
Mani Vinita E.,
Bhoi Sanjeev K.,
Misra Usha K.
Publication year - 2016
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/epi.13412
Subject(s) - scrub typhus , status epilepticus , medicine , typhus , orientia tsutsugamushi , pediatrics , doxycycline , magnetic resonance imaging , epilepsy , pathology , radiology , virology , antibiotics , psychiatry , microbiology and biotechnology , biology
Summary Scrub typhus is an emerging infection, and there is little information about status epilepticus ( SE ) in scrub typhus. We report the clinical spectrum and outcome of SE in scrub typhus. In a 3‐year prospective hospital‐based observational study, all scrub typhus patients with SE were included. Scrub typhus was diagnosed by immunochromatography assay. SE was defined if convulsions lasted longer than 5 min. The patients' demographic, clinical, computed tomography ( CT ), magnetic resonance imaging ( MRI ), and electroencephalography ( EEG ) findings were noted. Response to antiepileptic drugs ( AED s) and outcome at 1 month and 1 year were recorded. Between 2012 and 2014, there were 66 patients with scrub typhus admitted with central nervous system (CNS) involvement, 10 (15.2%) of whom had SE (generalized convulsions in 5, secondary generalized in one). The median age of the patients was 34 (range 18–71) years and seven were female. The duration of SE ranged between 10 min and 48 h. SE responded to one AED in five patients, two AED s in three patients, and more than two AED s in two patients. Cranial MRI findings were normal. All patients recovered completely with doxycycline by 1 month and AED was withdrawn by 8 months in all. Although 15% patients with scrub typhus may have SE , they have good outcome.