Premium
Serum inflammatory mediators correlate with disease activity in e lectrical s tatus e pilepticus in s leep (ESES) syndrome
Author(s) -
Munckhof Bart,
Vries Evelien E.,
Braun Kees P. J.,
Boss H. Myrthe,
Willemsen Michèl A.,
RoyenKerkhof Annet,
Jager Wilco,
Jansen Floor E.
Publication year - 2016
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/epi.13274
Subject(s) - chemokine , status epilepticus , cytokine , ccl3 , immunology , epilepsy , medicine , interleukin , receptor , inflammation , ccl2 , psychiatry
Summary We aimed to study serum cytokine levels in 11 electrical status epilepticus in sleep (ESES) patients and 20 healthy control children. Patients showed significantly higher levels of interleukin (IL)‐1α, IL‐6, IL‐10, chemokine (C‐C motif) ligand (CCL)2 and chemokine (C‐X‐C motif) ligand (CXCL)8/IL‐8 than controls, while macrophage migration inhibitory factor (MIF) and CCL3 were significantly lower. Follow‐up analyses in five patients revealed a significant decrease of IL‐6 levels after immunomodulating treatment. IL‐6 changes were accompanied by clear improvement of electroencephalography (EEG) patterns and neuropsychological evaluation. We hypothesize that IL‐6 correlates with disease activity and immunomodulating treatment efficacy.