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Resting‐state functional connectivity in the baboon model of genetic generalized epilepsy
Author(s) -
Salinas Felipe S.,
Szabó C. Ákos
Publication year - 2015
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/epi.13115
Subject(s) - default mode network , resting state fmri , neuroscience , baboon , spatial normalization , functional magnetic resonance imaging , functional connectivity , psychology , epilepsy , voxel , medicine , computer science , artificial intelligence
Summary Objective The baboon provides a natural model of genetic generalized epilepsy (GGE). This study compares the intrinsic connectivity networks of epileptic and healthy control baboons using resting‐state functional magnetic resonance imaging ( rs‐fMRI ) and data‐driven functional connectivity mapping. Methods Twenty baboons, matched for gender, age, and weight, were classified into two groups (10 epileptic [EPI], 10 control [CTL]) on the basis of scalp electroencephalography ( EEG ) findings. Each animal underwent one MRI session that acquired one 5‐min resting state fMRI scan and one anatomic MRI scan—used for registration and spatial normalization. Using independent component analysis, we identified 14 unique components/networks, which were then used to characterize each group's functional connectivity maps of each brain network. Results The epileptic group demonstrated network‐specific differences in functional connectivity when compared to the control animals. The sensitivity and specificity of the two groups' functional connectivity maps differed significantly in the visual, motor, amygdala, insular, and default mode networks. Significant increases were found in the occipital gyri of the epileptic group's functional connectivity map for the default mode, cingulate, intraparietal, motor, visual, amygdala, and thalamic regions. Significance This is the first study using resting‐state fMRI to demonstrate intrinsic functional connectivity differences between epileptic and control nonhuman primates. These results are consistent with seed‐based GGE studies in humans; however, our use of a data‐driven approach expands the scope of functional connectivity mapping to include brain regions/networks comprising the whole brain.