Premium
Epileptic encephalopathies: Optimizing seizure control and developmental outcome
Author(s) -
Jehi Lara,
Wyllie Elaine,
Devinsky Orrin
Publication year - 2015
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/epi.13107
Subject(s) - ictal , epilepsy , psychology , straddle , neuroscience , cognition , medicine , developmental psychology , finance , economics
Summary Cognitive and developmental outcomes in patients with epileptic encephalopathy are hypothesized to result from an interplay between the underlying epileptic pathologic substrate and the acquired consequences of frequent and repetitive seizures and epileptiform discharges that often straddle the interictal and ictal boundaries. This article briefly reviews the evidence related to this assumption, presents critical questions that need to be answered to clarify this relationship, and advances a set of concrete steps that may help improve developmental patient outcomes.