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Evaluation of focus laterality in temporal lobe epilepsy: A quantitative study comparing double inversion‐recovery MR imaging at 3 T with FDG‐PET
Author(s) -
Morimoto Emiko,
Okada Tomohisa,
Kanagaki Mitsunori,
Yamamoto Akira,
Fushimi Yasutaka,
Matsumoto Riki,
Takaya Shigetoshi,
Ikeda Akio,
Kunieda Takeharu,
Kikuchi Takayuki,
Paul Dominik,
Miyamoto Susumu,
Takahashi Ryosuke,
Togashi Kaori
Publication year - 2013
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/epi.12396
Subject(s) - laterality , epilepsy , temporal lobe , nuclear medicine , neuroscience , psychology , medicine
Summary Purpose To quantitatively compare the diagnostic capability of double inversion‐recovery ( DIR ) with F‐18 fluorodeoxyglucose positron emission tomography ( FDG ‐ PET ) for detection of seizure focus laterality in temporal lobe epilepsy ( TLE ). Methods This study was approved by the institutional review board, and written informed consent was obtained. Fifteen patients with TLE and 38 healthy volunteers were enrolled. All magnetic resonance ( MR ) images were acquired using a 3 T ‐ MRI system. Voxel‐based analysis ( VBA ) was conducted for FDG ‐ PET images and white matter segments of DIR images ( DIR ‐ WM ) focused on the whole temporal lobe ( TL ) and the anterior part of the temporal lobe ( ATL ). Distribution of hypometabolic areas on FDG ‐ PET and increased signal intensity areas on DIR ‐ WM were evaluated, and their laterality was compared with clinically determined seizure focus laterality. Correct diagnostic rates of laterality were evaluated, and agreement between DIR ‐ WM and FDG ‐ PET was assessed using κ statistics. Key Findings Increased signal intensity areas on DIR ‐ WM were located at the vicinity of the hypometabolic areas on FDG ‐ PET , especially in the ATL . Correct diagnostic rates of seizure focus laterality for DIR ‐ WM (0.80 and 0.67 for the TL and the ATL , respectively) were slightly higher than those for FDG ‐ PET (0.67 and 0.60 for the TL and the ATL , respectively). Agreement of laterality between DIR ‐ WM and FDG ‐ PET was substantial for the TL and almost perfect for the ATL (κ = 0.67 and 0.86, respectively). Significance High agreement in localization between DIR ‐ WM and FDG ‐ PET and nearly equivalent detectability of them show us an additional role of MRI in TLE.