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Epilepsy biomarkers
Author(s) -
Engel Jerome,
Pitkänen Asla,
Loeb Jeffrey A.,
Edward Dudek F.,
Bertram Edward H.,
Cole Andrew J.,
Moshé Solomon L.,
Wiebe Samuel,
Jensen Frances E.,
Mody Istvan,
Nehlig Astrid,
Vezzani Annamaria
Publication year - 2013
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/epi.12299
Subject(s) - epileptogenesis , epilepsy , biomarker , medicine , clinical trial , population , bioinformatics , biology , psychiatry , biochemistry , environmental health
Summary A biomarker is defined as an objectively measured characteristic of a normal or pathologic biologic process. Identification and proper validation of biomarkers of epileptogenesis (the development of epilepsy) and ictogenesis (the propensity to generate spontaneous seizures) might predict the development of an epilepsy condition; identify the presence and severity of tissue capable of generating spontaneous seizures; measure progression after the condition is established; and determine pharmacoresistance. Such biomarkers could be used to create animal models for more cost‐effective screening of potential antiepileptogenic and antiseizure drugs and devices, and to reduce the cost of clinical trials by enriching the trial population, and acting as surrogate markers to shorten trial duration. The objectives of the biomarker subgroup for the London Workshop were to define approaches for identifying possible biomarkers for these purposes. Research to identify reliable biomarkers may also reveal underlying mechanisms that could serve as therapeutic targets for the development of new antiepileptogenic and antiseizure compounds.