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Trafficking of NMDA receptors during status epilepticus: Therapeutic implications
Author(s) -
Wasterlain Claude G.,
Naylor David E.,
Liu Hantao,
Niquet Jerome,
Baldwin Roger
Publication year - 2013
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/epi.12285
Subject(s) - nmda receptor , status epilepticus , receptor , neuroscience , chemistry , dentate gyrus , glutamate receptor , biology , epilepsy , central nervous system , biochemistry
Summary We used two models of status epilepticus ( SE ) to study trafficking of N ‐methyl‐ d ‐aspartate ( NMDA ) receptors. SE is associated with increased surface expression of NR 1 subunits of NMDA receptors, and with an increase of NMDA synaptic and extrasynaptic currents suggesting an increase in number of functional NMDA receptors on dentate granule cells. The therapeutic implications of these results are discussed.