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Receptor trafficking hypothesis revisited: Plasticity of AMPA receptors during established status epilepticus
Author(s) -
Rajasekaran Karthik,
Joshi Suchitra,
Kozhemyakin Maxim,
Todorovic Marko S.,
Kowalski Samuel,
Balint Corinne,
Kapur Jaideep
Publication year - 2013
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/epi.12266
Subject(s) - ampa receptor , status epilepticus , neuroscience , receptor , synaptic plasticity , biology , medicine , epilepsy , glutamate receptor , genetics
Summary Status epilepticus ( SE ) is associated with a dynamic plasticity of postsynaptic neurotransmitter receptors. The plasticity of AMPA receptor ( AMPAR )–mediated glutamatergic transmission during established SE (ESE), after development of benzodiazepine resistance, was evaluated. There was increased frequency and inward rectification of AMPAR ‐mediated excitatory postsynaptic currents at S chaffer collateral ‐ CA 1 pyramidal neuron synapses during ESE . Surface expression of the G lu A 1 subunit increased, and this was a consequence of N ‐methyl‐ d ‐aspartate receptor activation. Further, diminishing glutamate release by activation of somatostatin receptors prevented SE . These studies suggest that AMPAR ‐mediated glutamatergic transmission is strengthened during ESE.