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Animal and human data: Where are our concepts for drug‐resistant epilepsy going?
Author(s) -
Potschka Heidrun
Publication year - 2013
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/epi.12181
Subject(s) - epilepsy , drug resistant epilepsy , drug resistance , drug , drug development , medicine , identification (biology) , intensive care medicine , psychology , pharmacology , psychiatry , biology , botany , microbiology and biotechnology
Summary Drug‐resistant epilepsy remains a challenge in the therapeutic management of patients with epilepsy. Identification of factors contributing to drug resistance might render a basis for the development of novel therapeutic approaches, for the reorganization of screening programs in drug development, and for the design of personalized treatment concepts. Therefore, experimental and clinical studies need to link efforts and collaborate in order to elucidate drug‐resistance mechanisms, to define the relative clinical relevance of selected mechanisms, and to develop and validate novel therapeutic concepts in overcoming resistance.