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The aim of this study was to quantify bisphenol A ( BPA ) concentrations in saliva and urine before and after treatment with dental polymer‐based restorative materials to assess if placement of this material is associated with increased  BPA  levels in saliva and urine. Twenty individuals in need of at least one dental restoration with polymer‐based restorative material were included in this study. The participants were instructed to abstain from eating, drinking, and brushing their teeth for at least 10 h prior to sampling. Saliva and urine were collected before and 10 min (saliva only), 1 h, 24 h, and 1 wk after treatment. Samples were stored at −80°C before analyses.  BPA  in saliva and urine was determined with liquid chromatography/mass spectrometry. Linear mixed effects regression models were used for statistical analyses. There was a statistically significant increase of salivary  BPA  concentration directly after placement of the dental polymer‐based restorations. Following placement, the concentration of  BPA  decreased exponentially with time. One week after treatment the  BPA  level in saliva was only marginally higher than before treatment. In urine, no statistically significant change of the  BPA  concentration was detected after treatment.

Bisphenol A in human saliva and urine before and after treatment with dental polymer‐based restorative materials