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Clinical association between chronic periodontitis and the leukocyte extravasation inhibitors developmental endothelial locus‐1 and pentraxin‐3
Author(s) -
Folwaczny Matthias,
Karnesi Evangelia,
Berger Tamara,
Paschos Ekaterini
Publication year - 2017
Publication title -
european journal of oral sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.802
H-Index - 93
eISSN - 1600-0722
pISSN - 0909-8836
DOI - 10.1111/eos.12357
Subject(s) - medicine , extravasation , periodontitis , chronic periodontitis , aggressive periodontitis , immunology , inflammation
This clinical study aimed to determine whether periodontal disease is associated with expression of developmental endothelial locus‐1 (Del‐1) and pentraxin‐3 ( PTX ‐3), endogenous inhibitors of leukocyte extravasation in humans. Expression of DEL1 , PTX 3 , interleukin‐17A ( IL 17A ), and lymphocyte function‐associated antigen‐1 ( LFA 1 ) was determined, using RT‐PCR and melting curve analysis, in biopsies of gingival tissues from 95 patients: 42 with moderate periodontitis; 40 with severe periodontitis; and 13 healthy controls. Relative expression of DEL1 and PTX 3 was statistically significantly weaker in patients with periodontitis than in the control subjects. On the contrary, both IL 17A and LFA 1 showed statistically significant stronger expression in patients with periodontitis than in healthy controls. Correlation analysis, performed using Spearman's test, showed that expression of DEL1 was statistically significantly linked to periodontitis ( ρ = −0.103) and to age ( ρ = −0.134), but not to the gender of the patient, and that expression of PTX 3 was significantly correlated with periodontitis ( ρ = −0.354). Expression of neutrophil extravasation inhibitors DEL1 and PTX 3 show significant, but weak, association with the clinical manifestation of chronic periodontitis.